tert-butyl 4-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylate → 5-chloro-3-(piperidin-4-yl)-1H-indole hydrochloride
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1>Cl.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1参加物
4
実験手順
tert-butyl 4-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylate (1 g; 2.99 mmol) was dissolved in 7.5 mL of a 4M solution of HCl in dioxane. The mixture was stirred at room temperature for 2 hours and was concentrated under reduced pressure to give quantitatively 5-chloro-3-(piperidin-4-yl)-1H-indole hydrochloride as a solid.
後処理
- concentrationwas concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-0fe0be036c7a41ae863ed6512e450b3c
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434722B2
反応ノート
読み込み中…