Chloroacetaldehyde → 7-phenyl-2,3-dihydro-1H-pyrrolizine

HRID 586640ノート

反応式

HRID 586640 の反応式
[CH2:1]([C:8]1[CH2:12][CH2:11][CH2:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])(O)=O.[Na+].Cl[CH2:19][CH:20]=O>CO>[C:2]1([C:1]2[CH:19]=[CH:20][N:9]3[C:8]=2[CH2:12][CH2:11][CH2:10]3)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 33ChloroacetaldehydeHCID 2240185-benzyl-3,4-dihydro-2H-pyrroleHCID 516892Sodium Bicarbonate

生成物 1

HCID 223355977-phenyl-2,3-dihydro-1H-pyrrolizine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

反応条件

温度
5 °C

実験手順

2-Benzyl-1-pyrroline (Example 1b, 85%, 74 g, 0.395 mol), dissolved in MeOH (360 ml), is treated with NaHCO3 (38 g, 0.45 mol), and the mixture is cooled to 5° C. A solution of chloroacetaldehyde (45% strength in water, 68 g, 0.4 mol), dissolved in MeOH (100 ml) is added dropwise to the solution at this temperature, and the mixture is stirred for 18 h with exclusion of light.

後処理

  1. additionis added dropwise to the solution at this temperature

出典と根拠

ORDレコード
ord-2c184a92199544a6b599d95f66902770
出典データセット
uspto-grants-2005_08
特許番号
US06936632B2

反応ノート

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