Ammonia → 2-Amino-6-fluoro-4-methoxybenzonitrile
反応式
[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[C:6](F)[C:3]=1[C:4]#[N:5].[NH3:13]>>[NH2:13][C:6]1[CH:7]=[C:8]([O:10][CH3:11])[CH:9]=[C:2]([F:1])[C:3]=1[C:4]#[N:5]参加物
3
反応条件
- 温度
- 140 °C
実験手順
2,6-Difluoro-4-methoxy-benzonitrile (Mol. Cryst. Liq. Cryst. 1989, 172) (200 mg, 1.18 mmol) was dissolved in ethanolic ammonia (2M solution, 10 ml) and the mixture was heated at 140° C. in an autoclave for 16 hours. The reaction mixture was cooled to room temperature and the solvent was evaporated under reduced pressure. The residue was purified by chromatography on silica gel using ethyl acetate in pentane as eluant (20:80) to give the title compound as a white solid (165 mg). LRMS: m/z (ES+) 189 [MNa+]
後処理
- temperatureThe reaction mixture was cooled to room temperature
- customthe solvent was evaporated under reduced pressure
- customThe residue was purified by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-d498532a0f0a47ce9d470456ed8f59b9
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06936619B2
反応ノート
読み込み中…