Acetic Anhydride → HCID 10149094、化合物

HRID 586752ノート

反応式

HRID 586752 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.C(N(CC)CC)C.[NH2:15][C:16]1[N:24]=[C:23]2[C:19]([NH:20][CH:21]=[N:22]2)=[C:18]([Cl:25])[N:17]=1>C1(C)C=CC=CC=1>[C:5]([N:22]1[CH:21]=[N:20][C:19]2[C:23]1=[N:24][C:16]([NH2:15])=[N:17][C:18]=2[Cl:25])(=[O:7])[CH3:6]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 53603492-Amino-6-chloropurine

生成物 1

HCID 10149094HCID 10149094、化合物収率 100%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

A mixture of 204.2 g (2.00 mol) of acetic anhydride, 202.4 g (2.00 mol) of triethylamine and 169.6 g (1.00 mol) of 2-amino-6-chloropurine was stirred at 80° C. for 1 hour. The resulting suspension was cooled at 25° C., and thereafter diluted with 400 mL of toluene, and the diluted solution was filtered. The resulting crystals were suspended in 300 mL of isopropanol, and the suspension was filtered again. The resulting crystals were dried at 60° C. under reduced pressure, to give 211.8 g of white powder of 9-acetyl-2-amino-6-chloropurine (yield 100%).

後処理

  1. temperatureThe resulting suspension was cooled at 25° C.
  2. filtrationthe diluted solution was filtered
  3. filtrationthe suspension was filtered again
  4. customThe resulting crystals were dried at 60° C. under reduced pressure

出典と根拠

ORDレコード
ord-c52926e774bb404f88c5c021b7c45a74
出典データセット
uspto-grants-2005_08
特許番号
US06936713B2

反応ノート

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