Triethylamine → HCID 66831931、化合物

HRID 58681

反応式

HRID 58681 の反応式
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH2:14].[CH3:15][C:16]1[O:20][N:19]=[C:18]([C:21](Cl)=[O:22])[CH:17]=1.C(N(CC)CC)C.C(OCC)(=O)C>ClCCl>[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH:14][C:21]([C:18]1[CH:17]=[C:16]([CH3:15])[O:20][N:19]=1)=[O:22]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 27368945-Methylisoxazole-3-carbonyl chlorideHCID 28274945-Chloro-1H-indole-3-ethylamine monohydrochloride

生成物 1

HCID 66831931HCID 66831931、化合物収率 68.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

This compound was obtained following Method B starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.046 g, 0.193 mmol), 5-methylisoxazole-3-carbonyl chloride (0.029 g; 0.193 mmol), and triethylamine (0.068 mL; 0.483 mmol) in dichloromethane (3 mL). Flash chromatography on silica gel eluting with 2 to 20% of ethyl acetate in dichloromethane gave 0.040 g (68%) of N-(2-(5-Chloro-1H-indol-3-yl)ethyl)-5-methylisoxazole-3-carboxamide as a solid.

後処理

  1. customThis compound was obtained

出典と根拠

ORDレコード
ord-528944b4ba094cb182eb486321bd8735
出典データセット
uspto-grants-2016_09
特許番号
US09434722B2

関連ノート

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