3-Hydroxybenzaldehyde → 3-Propoxybenzaldehyde

HRID 587001

反応式

HRID 587001 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH2:18][CH3:19].O>CN(C=O)C>[CH2:17]([O:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6])[CH2:18][CH3:19]

参加物

6

反応物 4

HCID 1013-HydroxybenzaldehydeHCID 962WaterHCID 78401-BromopropaneHCID 11430Potassium Carbonate

生成物 1

HCID 27604693-Propoxybenzaldehyde収率 99.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 3-hydroxybenzaldehyde (10.0 g) in DMF (120 ml) were added potassium carbonate (15.8 g) and 1-bromopropane (12.1 g), and the mixture was stirred under nitrogen atmosphere at room temperature overnight. Then, water was added to the mixture, which was extracted with ethyl acetate and washed with 1N sodium hydroxide solution twice, with water three times and with saturated brine once. After dried with magnesium sulfate, the solvent was evaporated under reduced pressure to give 3-propoxybenzaldehyde (13.4 g) as colorless liquid.

後処理

  1. extractionwas extracted with ethyl acetate
  2. washwashed with 1N sodium hydroxide solution twice
  3. dry with materialAfter dried with magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-e532573e9813427585e1ab5d71970579
出典データセット
uspto-grants-2005_08
特許番号
US06936602B1

関連ノート

読み込み中…