化工社化工社 化学情報印刷レポート · 研究参考用
2-Benzylpyrrolidine → 3-[(4-(2-Benzylpyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Benzylpyrrolidine | HCID 339556 | — |
| 反応物 | rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide | HCID 60197106 | — |
| 反応物 | 3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide | HCID 86679822 | — |
| 生成物 | 3-[(4-(2-Benzylpyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide | HCID 60197407 | — |
反応手順
B26 was prepared following the procedure reported for B4 using A1 and rac-2-benzylpyrrolidine. It was obtained as a white crystalline solid; yield: 160 mg (42%). 1H NMR (300 MHz, d6-DMSO, 300K) δ 1.67-1.92 (m, 4H), 2.57-2.77 (m, 1H), 3.03-3.21 (m, 1H), 3.42-3.62 (m, 2H), 4.20 (2 s, 2H), 4.28-4.48 (m, 1H), 6.88 (bs, 2H), 6.93-7.08 (m, 1H), 7.12-7.38 (m, 6H), 7.58 and 7.71 (2 m, 1H), 7.82-8.01 (m, 1H), 8.23 and 8.30 (2 s, 1H), 9.66 (bs, 1H). MS (ES) C21H24N6O2S requires: 424. found: 425 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09226929B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-19706696b23d4ebaaa621b9c708286c8 |
| 出典メモ | uspto-grants-2016_01 |