化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Amino-2-chloro-4-methylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Amino-4-picoline | HCID 137935 | — |
| 生成物 | 3-Amino-2-chloro-4-methylpyridine | HCID 2756387 | — |
反応手順
A mixture of 4-methylpyridin-3-amine (0.62 g), 12N hydrogen chloride (3.8 mL) and 30% hydrogen peroxide (0.75 mL) was stirred at 0° C. to room temperature for 1 h. The mixture was neutralized with K2CO3, and the mixture was extracted with AcOEt. The organic layer was dried over MgSO4, and concentrated in vacuo to give 2-chloro-4-methylpyridin-3-amine (0.75 g) as an orange solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09226921B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-64f6e6e1b99a4f8cb341f6242a1792fb |
| 出典メモ | uspto-grants-2016_01 |