関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Benzoic acid, 5-chloro-2-hydroxy-, methyl ester | HCID 77684 | — |
| 反応物 | 3-Bromocyclohexene | HCID 137057 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 2-(cyclohexen-3-yloxy)-5-chlorobenzoate | HCID 14621138 | — |
反応手順
A mixture of 18.6 g of methyl 5-chlorosalicylate, 28 g of K2CO3 and 20 g of 3-bromocyclohexene in 200 ml of DMF is stirred at 90° C. overnight. The mixture is then Poured into water, extracted with ethyl acetate, washed with water, dried over magnesium sulfate and evaporated to dryness to obtain crude product. This is purified by flash chromatography using hexane as the eluent to give pure methyl 2-(cyclohexen-3-yloxy)-5-chlorobenzoate as the first fraction which is used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05246942 |
|---|
| 出典データセット | uspto-grants-1993_09 |
|---|
| ORD ID | ord-e0690a28b3d54980b51fc455d392fbaf |
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| 出典メモ | uspto-grants-1993_09 |
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