Hydrochloric Acid → Methyl 4-amino-5-chloro-2-methoxybenzoate

HRID 5877

反応式

HRID 5877 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl.[CH3:15]O>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:15])=[O:6]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 816264-Amino-5-chloro-2-methoxybenzoic acid

生成物 1

HCID 700493Methyl 4-amino-5-chloro-2-methoxybenzoate

実験手順

To a solution of 50g of 2-methoxy-4-amino-5-chlorobenzoic acid in 500 ml of methanol is added HCl gas until all the material dissolves. Stirring is continued overnight, the solvent removed, ether added, filtered, dried over magnesium sulfate and evaporated to dryness to obtain methyl 2-methoxy-4-amino-5-chlorobenzoate which is used directly in the next step.

後処理

  1. dissolutiondissolves
  2. customthe solvent removed
  3. additionether added
  4. filtrationfiltered
  5. dry with materialdried over magnesium sulfate
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-1eb26c95049e45f5a0d34f4298931c2b
出典データセット
uspto-grants-1993_09
特許番号
US05246942

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