反応式
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH2:14].[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20]1[N:24]([CH3:25])[N:23]=[C:22]([C:26](Cl)=[O:27])[CH:21]=1.C(N(CC)CC)C.C(OCC)(=O)C>ClCCl>[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH:14][C:26]([C:22]1[CH:21]=[C:20]([C:16]2[O:15][CH:19]=[CH:18][CH:17]=2)[N:24]([CH3:25])[N:23]=1)=[O:27]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
This compound was obtained following Method B starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.100 g, 0.432 mmol), 5-(furan-2-yl)-1-methyl-1H-pyrazole-3-carbonyl chloride (0.096 g; 0.454 mmol), and triethylamine (0.156 mL; 1.08 mmol) in dichloromethane (2.87 mL). Flash chromatography on silica gel eluting with 5% of ethyl acetate in dichloromethane gave 0.121 g (98%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-5-(furan-2-yl)-1-methyl-1H-pyrazole-3-carboxamide as a solid.
後処理
- customThis compound was obtained
出典と根拠
- ORDレコード
- ord-688be8cd495042ddb4bb6d0758db412f
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434722B2
関連ノート
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