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4-[2-(4-Nitro-phenyl)-vinyl]-pyridine → 4-[2-(Pyridin-4-yl)ethyl]aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-[2-(4-Nitro-phenyl)-vinyl]-pyridine | HCID 307136 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-[2-(Pyridin-4-yl)ethyl]aniline | HCID 233288 | 100% |
反応手順
To the EtOAc solution (30 mL) of 4-[2-(4-nitro-phenyl)-vinyl]-pyridine (160 mg, 0.71 mmol) was added palladium on carbon (0.1 g, 50% wet). The suspension was hydrogenated at 50 psi of hydrogen for 2 hours. The mixture was filtered over a celite pad. The filtrate was concentrate to give 4-(2-pyridin-4-yl-ethyl)-phenylamine as a yellow solid (140 mg, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09227954B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-fbf0b7d100a3482ead33531dc2780fe1 |
| 出典メモ | uspto-grants-2016_01 |