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Triethylamine → Methyl 6-chloro-4-hydrazinonicotinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | Methyl4,6-dichloronicotinate | HCID 2764083 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Methyl 6-chloro-4-hydrazinonicotinate | HCID 45588417 | — |
反応手順
Into a 20-L 4-necked round-bottom flask was placed methyl 4,6-dichloropyridine-3-carboxylate (1200 g, 5.82 mol), ethanol (10 L), and triethylamine (1182 g, 11.68 mol). NH2NH2.H2O (351 g, 7.02 mol) was then added drop-wise to the reaction mixture at 0° C. The resulting solution was heated to reflux for 1 h. The reaction mixture was cooled to room temperature. The solid was collected by filtration to give methyl 6-chloro-4-hydrazinylnicotinate, which was carried onto the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09226922B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-f14e0ca123864c9ba7052da4033393ae |
| 出典メモ | uspto-grants-2016_01 |