Stannous chloride dihydrate → 4'-Amino-N-isopropylbiphenyl-4-sulfonamide

HRID 588342ノート

反応式

HRID 588342 の反応式
O.O.[Sn](Cl)Cl.[CH:6]([NH:9][S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=2)=[CH:15][CH:14]=1)(=[O:12])=[O:11])([CH3:8])[CH3:7]>CN(C=O)C>[NH2:25][C:22]1[CH:23]=[CH:24][C:19]([C:16]2[CH:17]=[CH:18][C:13]([S:10]([NH:9][CH:6]([CH3:8])[CH3:7])(=[O:12])=[O:11])=[CH:14][CH:15]=2)=[CH:20][CH:21]=1

参加物

4

反応物 2

HCID 61436Stannous chloride dihydrateHCID 59694089N-Isopropyl-4'-nitrobiphenyl-4-sulfonamide

生成物 1

HCID 596940904'-Amino-N-isopropylbiphenyl-4-sulfonamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

288.8 mg (1.28 mmol) of tin(II) chloride dihydrate are added to a solution of 100 mg (0.26 mmol) of N-isopropyl-4′-nitrobiphenyl-4-sulfonamide (Example 11A) in 2.0 ml of DMF. After 18 h at room temperature, the reaction mixture is purified by preparative HPLC. The product fractions are concentrated in vacuo and dried under high vacuum. 47 mg (63.2% of theory) of the title compound are obtained.

後処理

  1. customthe reaction mixture is purified by preparative HPLC
  2. concentrationThe product fractions are concentrated in vacuo
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-f6a37662251e439baafeab066957424c
出典データセット
uspto-grants-2016_01
特許番号
US09227964B2

反応ノート

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