L-Serine → L-Serine, methyl ester, hydrochloride (1:1)

Methanol (450 mL) in a round-bottom flask was cooled to 0° C. and acetyl chloride (55 mL, 0.77 mol) was added dropwise. After completion of the addition, the mixture was stirred at ambient temperature for 10 min and H-Ser-OH (30 g, 0.29 mol) was added in three portions. The reaction mixture was heated at 80° C. for 2 h and then concentrated. The residue was dried under vacuum to afford (S)-methyl 2-amino-3-hydroxypropanoate hydrochloride (quantitative) as a colorless solid, which was used in the next step without further purification.

1. additionAfter completion of the addition
2. temperatureThe reaction mixture was heated at 80° C. for 2 h
3. concentrationconcentrated
4. customThe residue was dried under vacuum

ORDレコード

ord-0aa4fe0dd32d40968fc32e8b983d26a1

出典データセット

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09434761B2