N-Methylcyclopropanamine → N4-Cyclopropyl-N4,1-dimethyl-N5-(2-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrazole-4,5-dicarboxamide
反応式
[CH:1]1([NH:4][CH3:5])[CH2:3][CH2:2]1.[CH3:6][N:7]1[C:11]([C:12](=[O:29])[NH:13][C:14]2[CH:15]=[CH:16][C:17]3[N:18]([N:20]=[C:21]([C:23]4[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=4)[N:22]=3)[CH:19]=2)=[C:10]([C:30](O)=[O:31])[CH:9]=[N:8]1>>[CH:1]1([N:4]([CH3:5])[C:30]([C:10]2[CH:9]=[N:8][N:7]([CH3:6])[C:11]=2[C:12]([NH:13][C:14]2[CH:15]=[CH:16][C:17]3[N:18]([N:20]=[C:21]([C:23]4[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=4)[N:22]=3)[CH:19]=2)=[O:29])=[O:31])[CH2:3][CH2:2]1参加物
3
実験手順
Using cyclopropyl-methyl-amine and 1-methyl-5-(2-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. White solid (71 mg, 44%). Mp.: 237° C. MS: m/z=417.3 (M+H+). Ames test negative.
出典と根拠
- ORDレコード
- ord-57a78f7b88cb4442abd09455b24eba89