Morpholine → 2-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid (2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

HRID 588445

反応式

HRID 588445 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:7][N:8]([CH3:30])[C:9]1[N:29]=[C:12]2[CH:13]=[CH:14][C:15]([NH:17][C:18]([C:20]3[N:24]([CH3:25])[N:23]=[CH:22][C:21]=3[C:26](O)=[O:27])=[O:19])=[CH:16][N:11]2[N:10]=1>>[CH3:7][N:8]([CH3:30])[C:9]1[N:29]=[C:12]2[CH:13]=[CH:14][C:15]([NH:17][C:18]([C:20]3[N:24]([CH3:25])[N:23]=[CH:22][C:21]=3[C:26]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:27])=[O:19])=[CH:16][N:11]2[N:10]=1

参加物

3

反応物 2

HCID 8083MorpholineHCID 894640535-(2-Dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid

生成物 1

HCID 715384172-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid (2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

実験手順

Using morpholine and 5-(2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. Off-white solid (117 mg, 58%). MS: m/z=399 (M+H+). Ames test negative.

出典と根拠

ORDレコード
ord-f7f77293352c48e7bd2feb1b1fe4950b
出典データセット
uspto-grants-2016_01
特許番号
US09227970B2

関連ノート

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