Methanol → Methyl cyclooctanecarboxylate

HRID 588672

反応式

HRID 588672 の反応式
[CH:1]1([CH:9]=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.OOS([O-])=O.[K+].[CH3:17][OH:18]>>[CH:1]1([C:9]([O:18][CH3:17])=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 3

HCID 887MethanolHCID 81190CyclooctanecarbaldehydeHCID 23707502Potassium hydroxy sulfite

生成物 1

HCID 77313Methyl cyclooctanecarboxylate

実験手順

To a solution of cyclooctanecarbaldehyde (5.0 g) in methanol (300 mL) was added Oxone (22 g). The mixture was stirred at room temperature for 18 hours. The reaction mixture was concentrated under vacuum and the residue was diluted with ethyl acetate (300 mL) and washed with 1N aqueous HCl, water, and brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to give the crude product.

後処理

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. additionthe residue was diluted with ethyl acetate (300 mL)
  3. washwashed with 1N aqueous HCl, water, and brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-5306a49dc82942aca8da0663f28ab36d
出典データセット
uspto-grants-2016_01
特許番号
US09227963B2

関連ノート

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