Methanol → Methyl tricyclo[3.3.1.13,7]decane-2-carboxylate

HRID 588679

反応式

HRID 588679 の反応式
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[C:11]([OH:13])=[O:12])[CH2:8]2.CO.[CH3:16][Si](C=[N+]=[N-])(C)C>C(OCC)(=O)C>[CH:3]12[CH2:9][CH:7]3[CH2:6][CH:5]([CH2:10][CH:1]([CH2:8]3)[CH:2]1[C:11]([O:13][CH3:16])=[O:12])[CH2:4]2

参加物

5

反応物 3

HCID 887MethanolHCID 167693TrimethylsilyldiazomethaneHCID 3038022-Adamantanecarboxylic acid

生成物 1

HCID 12600018Methyl tricyclo[3.3.1.13,7]decane-2-carboxylate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of adamantane-2-carboxylic acid 1 (0.486 g, 2.70 mmol) in ethyl acetate (10 mL)/methanol (5 mL) was dropwise added (trimethylsilyl)diazomethane (1.348 ml, 2.70 mmol) and the mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated and purified by flash chromotography (silica 40 g, 0%-30% ethyl acetate/hexanes).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by flash chromotography (silica 40 g, 0%-30% ethyl acetate/hexanes)

出典と根拠

ORDレコード
ord-a6b5f921f65d421298968a9096472616
出典データセット
uspto-grants-2016_01
特許番号
US09227963B2

関連ノート

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