HCID 86603565、化合物 → Imidazo[1,2-a]pyrazin-2-amine
反応式
FC(F)(F)C([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[N:12][CH:11]=[CH:10][N:9]2[CH:14]=1)=O>N.CO>[N:7]1[C:6]([NH2:5])=[CH:14][N:9]2[CH:10]=[CH:11][N:12]=[CH:13][C:8]=12参加物
4
反応条件
- 温度
- 68 °C
実験手順
2,2,2-Trifluoro-N-(imidazo[1,2-a]pyrazin-2-yl)acetamide (prepared as described in WO2004/058266A1, 520 mg) was dissolved in 7N NH3 in methanol (4.0 mL), and heated at 68° C. in a sealed tube for 6 hours. The reaction mixture was then cooled and concentrated to provide the title compound.
後処理
- temperatureThe reaction mixture was then cooled
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c5564128c32a40b78dc3757ec35a306a
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09227963B2
反応ノート
読み込み中…