tert-Butyl 4-(2-(4,5-dichloro-2-ethylphenylamino)acetyl)piperazine-1-carboxylate → 2-(4,5-Dichloro-2-ethylphenylamino)-1-(piperazin-1-yl)ethanone hydrochloride

HRID 588787ノート

反応式

HRID 588787 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][CH2:10][C:11]([N:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[O:12])=[C:4]([CH2:26][CH3:27])[CH:3]=1>Cl.CO>[ClH:1].[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][CH2:10][C:11]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[O:12])=[C:4]([CH2:26][CH3:27])[CH:3]=1

参加物

3

反応物 1

HCID 90459875tert-Butyl 4-(2-(4,5-dichloro-2-ethylphenylamino)acetyl)piperazine-1-carboxylate

生成物 1

HCID 1317344452-(4,5-Dichloro-2-ethylphenylamino)-1-(piperazin-1-yl)ethanone hydrochloride収率 161.5%

試薬・触媒・溶媒 1

HCID 21893726Hydrochloride methanol溶媒

実験手順

A mixture of tert-butyl 4-(2-(4,5-dichloro-2-ethylphenylamino)acetyl)piperazine-1-carboxylate (120 mg, 0.288 mmol) in HCl/MeOH (2.86 M, 10 mL) was stirred at room temperature for 1 h. The mixture was concentrated in vacuo to afford the crude product (82 mg) as a yellow solid which was used directly in the next step without further purification.

後処理

  1. concentrationThe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-3341256a78464f2f91a54e667bfdfa91
出典データセット
uspto-grants-2016_01
特許番号
US09227978B2

反応ノート

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