Hydrochloric Acid → 2-Amino-6-bromo-4-fluoro-3-nitrophenol

HRID 589132ノート

反応式

HRID 589132 の反応式
[Br:1][C:2]1[C:7]([OH:8])=[C:6]([N+:9]([O-])=O)[C:5]([N+:12]([O-:14])=[O:13])=[C:4]([F:15])[CH:3]=1.Cl>CO.O>[NH2:9][C:6]1[C:5]([N+:12]([O-:14])=[O:13])=[C:4]([F:15])[CH:3]=[C:2]([Br:1])[C:7]=1[OH:8]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 90410240HCID 90410240、化合物

生成物 1

HCID 904098182-Amino-6-bromo-4-fluoro-3-nitrophenol

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

6-Bromo-4-fluoro-2,3-dinitrophenol (4.4 g, 16 mmol) was stirred in methanol (88 mL) and 12.0 M hydrogen chloride in water (40 mL), followed by addition of stannous chloride dihydrate (11 g, 47 mmol) and the mixture was stirred at room temperature for 15 min. The mixture was diluted with water and extracted with ethyl acetate. The organic layer was separated and concentrated. Purification on silica gel eluting ethyl acetate in hexanes gave the amine product.

後処理

  1. extractionextracted with ethyl acetate
  2. customThe organic layer was separated
  3. concentrationconcentrated
  4. customPurification on silica gel
  5. washeluting ethyl acetate in hexanes

出典と根拠

ORDレコード
ord-a566e1f55c614dc2855a42c62da85f4a
出典データセット
uspto-grants-2016_01
特許番号
US09227985B2

反応ノート

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