Ammonium Hydroxide → 5-Chloropyrazolo[1,5-a]pyrimidin-7-amine

HRID 589153

反応式

HRID 589153 の反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1.[NH4+:12].[OH-]>>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:12])[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 110741545,7-Dichloropyrazolo[1,5-a]pyrimidine

生成物 1

HCID 231319095-Chloropyrazolo[1,5-a]pyrimidin-7-amine

反応条件

温度
85 °C

実験手順

To 5,7-dichloropyrazolo[1,5-a]pyrimidine (7.6 g, 40.4 mmol) in a sealed vessel was added NH4OH (100 mL). The vessel was then sealed and heated at 85° C. for 2.5 hours, at which time the consistency of the white solid had changed (from foamy white solid to free-flowing white solid). The vessel was removed from the heat source and allowed to cool to room temperature overnight. On cooling, the contents of the vessel were collected and dried by vacuum filtration giving 5-chloropyrazolo[1,5-a]pyrimidin-7-amine as a yellow-tinged white solid (6.8 g).

後処理

  1. customThe vessel was then sealed
  2. customThe vessel was removed from the heat source
  3. temperatureto cool to room temperature overnight
  4. temperatureOn cooling
  5. customthe contents of the vessel were collected
  6. customdried by vacuum filtration

出典と根拠

ORDレコード
ord-62ddcfe51f8a41c18e1c5170c8284292
出典データセット
uspto-grants-2016_01
特許番号
US09227971B2

関連ノート

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