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HRID 58946作成日：2026年10月26日
Triethylamine → 5-methyl-1-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-1H-pyrazole-4-carboxylic acid pyridazin-4-ylamide
https://huagongshe.com/reaction/58946
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Aminopyridazine | HCID 298492 | — |
| 反応物 | 5-Methyl-1-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]pyrazole-4-carbonyl chloride | HCID 89157399 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-methyl-1-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-1H-pyrazole-4-carboxylic acid pyridazin-4-ylamide | HCID 89157052 | 90% |
反応手順
A solution of 398 mg 5-methyl-1-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]pyrazole-4-carbonyl chloride in 10 ml CH2Cl2 was added dropwise to a solution of 185 mg pyridazin-4-amine and 750 mg triethylamine in 30 ml CH2Cl2 at 0° C. The mixture was stirred at 20-25° C. for about 68 h, diluted with 25 ml ethylacetate, washed with 3×15 ml sat. aq. NH4Cl solution, dried over MgSO4 and evaporated. Purification by flash chromatography (CH2Cl2/MeOH) gave 160 mg of the title compound (90% purity). HPLC-MS (Method 1): RT 2.278 min, m/z [MH]+ 354.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09439427B2 |
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| 出典データセット | uspto-grants-2016_09 |
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| ORD ID | ord-cac05d61e4014455854aabbd99dbcd36 |
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| 出典メモ | uspto-grants-2016_09 |
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