反応式
Br[C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[C:3]=1[CH:4]=[O:5].CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.C([O-])([O-])=O.[Cs+].[Cs+].[OH:59][C:60]([C:63]1[CH:64]=[C:65]2[C:70](=[CH:71][CH:72]=1)[C:69](=[O:73])[NH:68][CH2:67][CH2:66]2)([CH3:62])[CH3:61]>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].O>[Br:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([N:68]2[CH2:67][CH2:66][C:65]3[C:70](=[CH:71][CH:72]=[C:63]([C:60]([OH:59])([CH3:61])[CH3:62])[CH:64]=3)[C:69]2=[O:73])[C:3]=1[CH:4]=[O:5]参加物
8
反応物 4
生成物 1
試薬・触媒・溶媒 3
実験手順
To a mixture of 2,6-dibromo-benzaldehyde (1.60 g, 6.06 mmol), Pd2(dba)3 (222 mg, 0.243 mmol), xantphos (210 mg, 0.364 mmol), and Cs2CO3 (2.77 g, 8.49 mmol) in dioxane (60 ml) under argon was added 6-(1-hydroxy-1-methyl-ethyl)-3,4-dihydro-2H-isoquinolin-1-one (US2009/0306041) (995 mg, 4.85 mmol). The resulting mixture was refluxed overnight. After cooling down to r.t., water was added, and the mixture was extracted three times with EtOAc. The combined organic layers were dried, filtered, and evaporated to dryness. The crude product was purified by flash chromatography (silica gel, cyclohexane/EtOAC gradient) to yield Intermediate 42.
後処理
- temperatureThe resulting mixture was refluxed overnight
- extractionthe mixture was extracted three times with EtOAc
- customThe combined organic layers were dried
- filtrationfiltered
- customevaporated to dryness
- customThe crude product was purified by flash chromatography (silica gel, cyclohexane/EtOAC gradient)
出典と根拠
- ORDレコード
- ord-90af4d69beb0411eb58739cf642e7ca0
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09233111B2
関連ノート
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