Acetyl chloride → Methyl 2-amino-6-methylisonicotinate
反応式
[C:1](Cl)(=O)C.[NH2:5][C:6]1[CH:7]=[C:8]([CH:12]=[C:13]([CH3:15])[N:14]=1)[C:9]([OH:11])=[O:10]>CO>[CH3:1][O:10][C:9](=[O:11])[C:8]1[CH:12]=[C:13]([CH3:15])[N:14]=[C:6]([NH2:5])[CH:7]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To 50 ml of MeOH is added drop wise acetyl chloride (3 ml) at room temperature. After 15 min, 2-amino-6-methylisonicotinic acid (2.3 g) is added and the mixture is stirred overnight at 50° C. After concentrating the solution, the resulting residue is suspended in acetone and then filtered and dried at 50° C. in vacuum, to yield 2-amino-6-methylisonicotinic acid methyl ester (4.1 g). HPLC: Rt=0.91 min (method D)
後処理
- concentrationAfter concentrating the solution
- filtrationfiltered
- customdried at 50° C. in vacuum
出典と根拠
- ORDレコード
- ord-0cfaa94616194598af872bc0c56dfea8
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09233950B2
反応ノート
読み込み中…