Phosphorus oxychloride → 5-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride

HRID 589670ノート

反応式

HRID 589670 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10](O)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1.O=P(Cl)(Cl)[Cl:18]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([Cl:18])(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178554105-Fluoro-3-methylbenzothiophene-2-sulfonic acid

生成物 1

HCID 27745865-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride収率 93%

反応条件

温度
60 °C

実験手順

A mixture of 5-fluoro-3-methylbenzothiophene-2-sulfonic acid (230 mg, 0.93 mmol) in POCl3 (5 mL) was heated at 60° C. over night. The POCl3 was evaporated and the crude product was dissolved in CH2Cl2 and washed with water. The organic phase was dried and evaporated to give 0.23 g (93%) of the title compound.

後処理

  1. customThe POCl3 was evaporated
  2. dissolutionthe crude product was dissolved in CH2Cl2
  3. washwashed with water
  4. customThe organic phase was dried
  5. customevaporated

出典と根拠

ORDレコード
ord-fe9222313f924dadb315294cf65a9697
出典データセット
uspto-grants-2016_01
特許番号
US09233946B2

反応ノート

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