5-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride → HCID 178432000、化合物

HRID 589710ノート

反応式

HRID 589710 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10](Cl)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1.[NH2:16][C:17]1[CH:18]=[C:19]([C:23]2[NH:27][N:26]=[N:25][N:24]=2)[CH:20]=[CH:21][CH:22]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]4[NH:27][N:26]=[N:25][N:24]=4)[CH:18]=3)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1

参加物

3

反応物 2

HCID 27745865-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride2 回HCID 178507542HCID 178507542、化合物

生成物 1

HCID 178432000HCID 178432000、化合物収率 36%

実験手順

The product was prepared according to General Procedure 1, described in Example 1, starting from 5-fluoro-3-methylbenzothiophene-2-sulfonyl chloride (Intermediate 14) (26 mg, 0.10 mmol) and 5-(3-amino-phenyl)tetrazole (31 mg, 0.19 mmol). The title compound was obtained in 36% yield (13.9 mg). MS (ESI+) calcd for C16H12FN5O2S2 389.041644, found 389.042334.

後処理

  1. customThe product was prepared

出典と根拠

ORDレコード
ord-e81738f6c1474d4689b642b53cd9f48a
出典データセット
uspto-grants-2016_01
特許番号
US09233946B2

反応ノート

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