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3-Aminobenzoic Acid → 3-{[(5-Fluoro-3-methyl-1-benzothiophen-2-yl)sulfonyl]amino}benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminobenzoic Acid | HCID 7419 | — |
| 反応物 | 5-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride | HCID 2774586 | — |
| 生成物 | 3-{[(5-Fluoro-3-methyl-1-benzothiophen-2-yl)sulfonyl]amino}benzoic acid | HCID 56941889 | 45% |
反応手順
The product was prepared according to General Procedure 1, described in Example 1, with 5-fluoro-3-methylbenzothiophene-2-sulfonyl chloride (Intermediate 14) (26 mg, 0.10 mmol) and 3-aminobenzoic acid (26 mg, 0.19 mmol). The title compound was obtained in 45% yield (16.5 mg). MS (ESI+) calcd mass for C16H12FNO4S2 365.019178, found 365.018988.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09233946B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-740018a01f134d068d04b74f1a524ef6 |
| 出典メモ | uspto-grants-2016_01 |