Hydrochloric Acid → 2-(2,6-Dimethylpiperazin-1-yl)pyrimidine hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH:12]([CH3:14])[N:11]([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH:10]([CH3:21])[CH2:9]1)=O)(C)(C)C.[ClH:22]>C(O)C>[ClH:22].[CH3:21][CH:10]1[CH2:9][NH:8][CH2:13][CH:12]([CH3:14])[N:11]1[C:15]1[N:16]=[CH:17][CH:18]=[CH:19][N:20]=1参加物
4
実験手順
3,5-Dimethyl-4-pyrimidin-2-ylpiperazine-1-carboxylic acid tert-butyl ester (294 mg) was dissolved in ethanol (2 ml), 4N hydrochloric acid (ethyl acetate solution, 2 ml) was added and the mixture was stirred at room temperature for 4 hr. The solvent was evaporated, and ethyl acetate (3 ml) was added to the obtained residue. The solid insoluble in ethyl acetate was collected by filtration and dried to give the title compound (281 mg).
後処理
- customThe solvent was evaporated
- additionethyl acetate (3 ml) was added to the obtained residue
- filtrationThe solid insoluble in ethyl acetate was collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-014cdd280ff74bbc90231b19d4f3dd78
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09233969B2
反応ノート
読み込み中…