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Benzoyl Peroxide → 3-Bromo-2-(4-chlorobenzylidene)indan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl Peroxide | HCID 7187 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 2-(p-Chlorobenzylidene)-1-indanone | HCID 367217 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 3-Bromo-2-(4-chlorobenzylidene)indan-1-one | HCID 68748582 | — |
反応手順
2-(4-chlorobenzylidene)indan-1-one (2.44 g, 9.58 mmol) was dissolved in 35 mL of CCl4. N-bromosuccinimide (1.685 g, 9.58 mmol) and benzoyl peroxide (122 mg, 0.52 mmol) were added in one portion. The solution was then stirred under reflux for one hour and then filtered once cooled to room temperature. The precipitate was separated using flash column chromatography (15:1 Hexanes/EtOAc) provided 14a as white crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09439877B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-814d39fdb22b4d17948eb2814524dcdd |
| 出典メモ | uspto-grants-2016_09 |