tert-Butyl (4-hydroxynaphthalen-1-yl)carbamate → Tert-butyl 4-(2-amino-3-nitropyridin-4-yloxy)naphthalen-1-ylcarbamate

HRID 59038

反応式

HRID 59038 の反応式
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:4][CH:3]=1.[NH2:20][C:21]1[C:26]([N+:27]([O-:29])=[O:28])=[C:25](OC2C=CC(NC(=O)OC(C)(C)C)=C(F)C=2)[CH:24]=[CH:23][N:22]=1>>[C:15]([O:14][C:13](=[O:19])[NH:12][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([O:1][C:25]2[CH:24]=[CH:23][N:22]=[C:21]([NH2:20])[C:26]=2[N+:27]([O-:29])=[O:28])=[CH:3][CH:4]=1)([CH3:16])([CH3:18])[CH3:17]

参加物

3

反応物 2

HCID 10923237tert-Butyl (4-hydroxynaphthalen-1-yl)carbamateHCID 44185771Tert-butyl 4-(2-amino-3-nitropyridin-4-yloxy)-2-fluorophenylcarbamate

生成物 1

HCID 44186165Tert-butyl 4-(2-amino-3-nitropyridin-4-yloxy)naphthalen-1-ylcarbamate

実験手順

The title compound was prepared from tert-butyl 4-hydroxynaphthalen-1-ylcarbamate (Regan, J. et al, J. Med. Chem., 2002, Vol. 45, No. 14, p. 2994) (3.9 g, 15 mmol) by the same method as described for compound (3a).

出典と根拠

ORDレコード
ord-278ad52100f24a739d1fc5422f8d7d68
出典データセット
uspto-grants-2016_09
特許番号
US09439893B2

関連ノート

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