Hydrochloric Acid → 6-Amino-9-[3-(1-azetidinyl)propyl]-2-(butyloxy)-7,9-dihydro-8H-purin-8-one

HRID 590493ノート

反応式

HRID 590493 の反応式
[N:1]1([CH2:5][CH2:6][CH2:7][N:8]2[C:16]([O:17]C)=[N:15][C:14]3[C:9]2=[N:10][C:11]([O:20][CH2:21][CH2:22][CH2:23][CH3:24])=[N:12][C:13]=3[NH2:19])[CH2:4][CH2:3][CH2:2]1.Cl.O1CCOCC1>CO>[NH2:19][C:13]1[N:12]=[C:11]([O:20][CH2:21][CH2:22][CH2:23][CH3:24])[N:10]=[C:9]2[C:14]=1[NH:15][C:16](=[O:17])[N:8]2[CH2:7][CH2:6][CH2:5][N:1]1[CH2:2][CH2:3][CH2:4]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 592526009-[3-(1-Azetidinyl)propyl]-2-(butyloxy)-8-(methyloxy)-9H-purin-6-amine

生成物 1

HCID 592526036-Amino-9-[3-(1-azetidinyl)propyl]-2-(butyloxy)-7,9-dihydro-8H-purin-8-one収率 104%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

9-[3-(1-Azetidinyl)propyl]-2-(butyloxy)-8-(methyloxy)-9H-purin-6-amine (13 mg, 0.039 mmol) was dissolved in methanol (3 ml) and 4M hydrogen chloride in 1,4-dioxane (0.243 ml, 0.972 mmol) was added and the mixture stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue was dissolved in methanol and loaded onto an aminopropyl SPE cartridge (2 g). The cartridge was eluted with methanol and the solvent removed to give the title compound as a white solid (13 mg).

後処理

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in methanol
  3. washThe cartridge was eluted with methanol
  4. customthe solvent removed

出典と根拠

ORDレコード
ord-1dec85ec79324cffb8b355380e3d76e3
出典データセット
uspto-grants-2016_01
特許番号
US09233962B2

反応ノート

読み込み中…