関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methylglyoxal | HCID 880 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Glycinehydroxamic acid | HCID 94811 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178430963 | HCID 178430963 | 57.7% |
反応手順
100 mmol (9 g) glycine hydroxamic acid were cooled to −25° C. in 200 ml water and methanol each, 100 mmol (15.4 ml 40% solution) methylglyoxal were added dropwise and subsequently the pH was adjusted to approximately pH 11 with 10 ml 30% NaOH. Heating up to 5° C. was carried out in 2 h and concentrated under vacuum to half of the solvent volume. A pH 3 was adjusted with 20% HCl, precipitated solid was filtered off and dried. 7.28 g (52% yield) of the title compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09439910B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-4d7c9ee2a2db4964a663905b500c8598 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
