化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → Methyl 3-amino-2-methylpropanoate hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Beta-Aminoisobutyric Acid | HCID 64956 | — |
| 生成物 | Methyl 3-amino-2-methylpropanoate hydrochloride | HCID 13063725 | — |
反応手順
To the solution of DL-3-aminoisobutyric acid (CAS number: 144-90-1, Aldrich) (2.7 g, 26.4 mmol) in MeOH (50 mL) was added SOCl2 (6.17 g, 52.8 mmol) dropwise at 0° C. under N2 atmosphere. The reaction was refluxed for 18 hours. The solvent was removed in vacuo to give crude Compound W which was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09233978B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-3bdec371188e4bf5bf7e54409d90ba2b |
| 出典メモ | uspto-grants-2016_01 |