(S)-2-tert-Butoxycarbonylamino-5-oxo-hexanoic acid ethyl ester → (S)-ethyl 5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

HRID 590655ノート

反応式

HRID 590655 の反応式
C(OC([NH:8][C@@H:9]([CH2:15][CH2:16][C:17](=O)[CH3:18])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=O)(C)(C)C>FC(F)(F)C(O)=O.ClCCl>[CH3:18][C:17]1[CH2:16][CH2:15][C@@H:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:8]=1

参加物

3

反応物 1

HCID 58544329(S)-2-tert-Butoxycarbonylamino-5-oxo-hexanoic acid ethyl ester

生成物 1

HCID 67682752(S)-ethyl 5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

試薬・触媒・溶媒 1

HCID 21863450Trifluoroacetic acid methylene chloride溶媒

実験手順

(S)-ethyl 2-(tert-butoxycarbonylamino)-5-oxohexanoate in a 1 L flask was treated with a trifluoro acetic acid/dichloromethane solution (1:1 mixture, 100 mL). Effervescence was observed and the mixture was allowed to stir for 4 hours at room temperature. After which time the volatiles were removed in vacuo to yield (S)-ethyl 5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate as an oil, and used directly in the following step.

後処理

  1. customAfter which time the volatiles were removed in vacuo

出典と根拠

ORDレコード
ord-ca24f42a36cb477aa0980ecb8c115b9e
出典データセット
uspto-grants-2016_01
特許番号
US09233974B2

反応ノート

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