(1R)-(+)-1-(4-Fluorophenyl)ethylamine → (R)-1-(1-(4-fluorophenyl)ethyl)urea

HRID 590774ノート

反応式

HRID 590774 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH2:10])[CH3:9])=[CH:4][CH:3]=1.[O-:11][C:12]#[N:13].[K+]>Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH:10][C:12]([NH2:13])=[O:11])[CH3:9])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6950187(1R)-(+)-1-(4-Fluorophenyl)ethylamineHCID 11378442Potassium cyanate

生成物 1

HCID 117601722(R)-1-(1-(4-fluorophenyl)ethyl)urea

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
80 °C

実験手順

(R)-1-(4-Fluorophenyl)ethanamine (5.15 g, 37.0 mmol) was taken up in HCl (2N, 40 mL) and potassium cyanate (15.01 g, 185 mmol) was added. The mixture was stirred at 80° C. for 3 h. Upon cooling to room temperature, a precipitate formed which was collected by filtration and washed with water. The solid was partitioned between water and EtOAc, and the aqueous phase extracted once more with EtOAc. The combined organic extracts were dried over Na2SO4, filtered, and concentrated in vacuo to give (R)-1-(1-(4-fluorophenyl)ethyl)urea. MS ESI calc'd. for C9H11FN2O [M+1]+ 183. found 183.

後処理

  1. temperatureUpon cooling to room temperature
  2. customa precipitate formed which
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customThe solid was partitioned between water and EtOAc
  6. extractionthe aqueous phase extracted once more with EtOAc
  7. dry with materialThe combined organic extracts were dried over Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-d36bd88c69534b799ea41fc4267c8c23
出典データセット
uspto-grants-2016_01
特許番号
US09233979B2

反応ノート

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