関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4,4-Difluoropiperidine | HCID 2758352 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | 2,4-Dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine | HCID 117820912 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-Chloro-4-(4,4-difluoropiperidin-1-yl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine | HCID 117821130 | — |
反応手順
To an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (0.120 g, 0.46 mmol) in acetonitrile (2 mL) was a solution of 4,4-difluoropiperidine (0.217 g, 1.38 mmol) and sodium methoxide (30 wt % in methanol, 0.188 mL, 1.01 mmol) in MeOH (2 mL) added. The reaction was stirred at 0° C. for 2 hours. Water and DMF was added and the residue was purified by preparative HPLC to give the title compound as a dry film (0.110 g, 69%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09439904B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-379d10dffd7146a1a029057eb2a721b8 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
