(2-Bromo-5-phenylthiophen-3-yl)methanol → 2-Bromo-5-phenylthiophene-3-carbaldehyde
反応式
[Br:1][C:2]1[S:3][C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][C:6]=1[CH2:7][OH:8]>ClCCl.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[S:3][C:4]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][C:6]=1[CH:7]=[O:8]参加物
4
実験手順
A solution of (2-bromo-5-phenylthiophen-3-yl)methanol (11e) (220 mg, 0.83 mmol) and manganese dioxide (720 mg, 8.3 mmol) in dichloromethane (3 mL) was stirred at room temperature for 160 minutes. The reaction mixture was filtered over Celite® and the filtrate was evaporated to dryness to provide the desired aldehyde (11f) (180 mg, 0.67 mmol, 81%), which was used without further purification.
後処理
- filtrationThe reaction mixture was filtered over Celite®
- customthe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-397225a12090406a930f4564adc66fd2
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09238026B2
反応ノート
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