Sulfuric Acid → 8-Chloro-4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

関与物質

反応手順

To ethyl 4-chloro-3-oxobutanoate (4.91 mL) was added sulfuric acid (12.91 mL) at 0° C., then was added 2-chlorobenzene-1,3-diol (5.0 g) in several portions at 0° C. The mixture was warmed to room temperature and stirred at the same temperature for 2 h. The reaction mixture was poured into water under stirring at 0° C. The precipitate was collected by m filtration and washed with hexane to give the title compound (2.78 g).

情報源と証拠