[Cl:1][C:2]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:3]=1[CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12]CC)=O)=[C:8](F)[CH:7]=1.O.[OH-].[Li+].[SH:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29]>CN(C=O)C.O>[Cl:1][C:2]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:3]=1[CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]2[C:10]([OH:12])=[C:27]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[S:26][C:8]=2[CH:7]=1To a mixture of ethyl 4-((2,4-dichlorobenzyl)oxy)-2-fluorobenzoate (2.0 g) in DMF (dry) (40 mL) were added lithium hydroxide monohydrate (0.978 g) and ethyl 2-mercaptoacetate (1.92 mL) at room temperature. The mixture was stirred at room temperature for 2 d. The mixture was diluted with water and the precipitate was collected by filtration, and washed with IPE to give the title compound (2.30 g).
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