2-Chloro-3,5-dimethylpyrazine → 2-Ethenyl-3,5-dimethylpyrazine
反応式
Cl[C:2]1[C:7]([CH3:8])=[N:6][C:5]([CH3:9])=[CH:4][N:3]=1.[CH:10]([B-](F)(F)F)=[CH2:11].[K+]>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].CCO>[CH3:8][C:7]1[C:2]([CH:10]=[CH2:11])=[N:3][CH:4]=[C:5]([CH3:9])[N:6]=1参加物
5
実験手順
To a mixture of 2-chloro-3,5-dimethylpyrazine (2 g) and EtOH (20 mL) were added potassium vinyltrifluoroborate (2.067 g) and TEA (2.93 mL) at room temperature, and the mixture was stirred under nitrogen atmosphere. To the mixture was added PdCl2(dppf) (1.026 g), and the mixture was refluxed for 2 h.
後処理
- temperaturethe mixture was refluxed for 2 h.
出典と根拠
- ORDレコード
- ord-80f9858156f349028a806eff8d73f561
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09238639B2
反応ノート
読み込み中…