Water → 4-Acetamido-3-iodobenzaldehyde

HRID 591679ノート

反応式

HRID 591679 の反応式
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([I:13])[CH:4]=1.O>CS(C)=O>[CH:2]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([I:13])[CH:4]=1)=[O:1]

参加物

4

反応物 2

HCID 962WaterHCID 66745042N-(4-(Hydroxymethyl)-2-iodophenyl)acetamide

生成物 1

HCID 229919464-Acetamido-3-iodobenzaldehyde

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

To a solution of IBX (0.93 g, 3.3 mmol) in dimethylsulfoxide (3.5 mL) was added N-(4-hydroxymethyl-2-iodo-phenyl)-acetamide (0.87 g, 3.0 mmol) and the reaction mixture was stirred at room temperature for 1 hour. Water (50 mL) was added and the solid was separated by filtration, and washed with ethyl acetate (20 mL). The filtrate was collected and extracted with ethyl acetate (200 mL). The organic phase was washed with brine (100 mL) and dried over anhydrous Na2SO4. Removal of solvent gave N-(4-formyl-2-iodo-phenyl)-acetamide as a light brown solid. Yield: 0.82 g (95%).

後処理

  1. customthe solid was separated by filtration
  2. washwashed with ethyl acetate (20 mL)
  3. customThe filtrate was collected
  4. extractionextracted with ethyl acetate (200 mL)
  5. washThe organic phase was washed with brine (100 mL)
  6. dry with materialdried over anhydrous Na2SO4
  7. customRemoval of solvent

出典と根拠

ORDレコード
ord-932f32110be646afa950cb72c7fb2cf3
出典データセット
uspto-grants-2016_01
特許番号
US09238640B2

反応ノート

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