1-Bromo-2-Chloroethane → 3-(2-Chloroethyl)Benzoselenazolinone

HRID 5917

反応式

HRID 5917 の反応式
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][CH2:9][Cl:10].[Se:11]1(=[O:20])[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=[CH:12]1>CN(C)C=O>[Cl:10][CH2:9][CH2:8][N:13]1[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Se:11](=[O:20])[CH2:12]1

参加物

5

反応物 3

HCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium CarbonateHCID 87879929Benzoselenazolinone

生成物 1

HCID 867472273-(2-Chloroethyl)Benzoselenazolinone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

0.06 mol of potassium carbonate and then 0.015 mol of 1-bromo-2-chloroethane are added to a solution of 0.015 mol of benzoselenazolinone in 30 cm3 of dimethylformamide. The mixture is heated to 50° C. with stirring for six hours. The inorganic precipitate is drained and then washed with dimethyl formamide. The DMF is evaporated off under reduced pressure and the residue is taken up with water. An extraction with ether is then carried out. The organic phase is dried over sodium sulfate and then filtered. The ether phase is evaporated to dryness under reduced pressure and the product is recrystallized in petroleum ether.

後処理

  1. washwashed with dimethyl formamide
  2. customThe DMF is evaporated off under reduced pressure
  3. extractionAn extraction with ether
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. filtrationfiltered
  6. customThe ether phase is evaporated to dryness under reduced pressure
  7. customthe product is recrystallized in petroleum ether

出典と根拠

ORDレコード
ord-f45c559759264321ac72a2b37dcee8d3
出典データセット
uspto-grants-1993_09
特許番号
US05246951

関連ノート

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