Methanol → 7-fluoro-5-methoxy-2-pyridin-4-yl-3H-quinazolin-4-one

HRID 591799ノート

反応式

HRID 591799 の反応式
F[C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:19])[NH:5][C:6]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)=[N:7]2.[CH3:20][O-:21].[Na+].CO.O>CN(C=O)C.C(O)(=O)C>[F:12][C:10]1[CH:9]=[C:8]2[C:3]([C:4](=[O:19])[NH:5][C:6]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[N:7]2)=[C:2]([O:21][CH3:20])[CH:11]=1

参加物

7

反応物 4

HCID 887MethanolHCID 962WaterHCID 10942334Sodium MethoxideHCID 1363794005,7-difluoro-2-pyridin-4-yl-3H-quinazolin-4-one

生成物 1

HCID 1363480537-fluoro-5-methoxy-2-pyridin-4-yl-3H-quinazolin-4-one

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a suspension of 5,7-difluoro-2-pyridin-4-yl-3H-quinazolin-4-one (0.20 g, 0.80 mmol) in DMF (3 mL) was added sodium methoxide in methanol (0.43 g, 8.0 mmol) and the reaction mixture was stirred at room temperature for 16 hours. Water was added, the mixture was acidified with acetic acid to pH approximately 4-5, and the precipitated solid was filtered off to obtain 7-fluoro-5-methoxy-2-pyridin-4-yl-3H-quinazolin-4-one as a yellowish solid. Yield: 0.20 g (83%).

後処理

  1. filtrationthe precipitated solid was filtered off

出典と根拠

ORDレコード
ord-69d7f965874e4b4c8ae05f4b31332b45
出典データセット
uspto-grants-2016_01
特許番号
US09238640B2

反応ノート

読み込み中…