Ammonium Acetate → HCID 178489871、化合物

関与物質

反応手順

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50.00 mg, 0.1702 mmol), 6-Methoxy-pyridine-2-carbaldehyde (25.7 mg, 0.187 mmol), and Ammonium acetate (26.2 mg, 0.340 mmol) were reacted to produce 11.03 mg (19%) of the title compound. (300 MHz, DMSO-d6) 13.30 (s, 1H), 8.01 (s, 1H), 7.89 (t, J=15 Hz, 7.5 Hz, 1H), 7.79 (m, 2H), 7.30 (d, J=9 Hz, 1H), 7.25 (s, 1H), 6.90 (d, J=8 Hz, 1H), 6.44 (s, 1H), 6.37 (s, 1H), 5.17 (t, J=17 Hz, J=9 Hz, 1H), 4.06 (s, 3H), 2.90 (s, 1H), 2.82 (s, 1H), 2.63 (d, J=8 Hz, 1H), 2.24 (d, J=8 Hz, 1H), 1.39 (d, J=8 Hz, 1H). MS=411 (M+H), HPLC: 2.53 min. (G Method)

情報源と証拠