Ammonium Acetate → HCID 178489871、化合物

HRID 592001

反応式

HRID 592001 の反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([NH:9][C@@H:10]2[C@@H:15]3[CH2:16][C@@H:12]([CH:13]=[CH:14]3)[C@@H:11]2[C:17]([NH2:19])=[O:18])[C:5]([Cl:20])=[CH:4][N:3]=1.[CH3:21][O:22][C:23]1[N:28]=[C:27]([CH:29]=O)[CH:26]=[CH:25][CH:24]=1.C([O-])(=O)C.[NH4+]>>[Cl:20][C:5]1[C:6]([NH:9][C@@H:10]2[C@@H:15]3[CH2:16][C@@H:12]([CH:13]=[CH:14]3)[C@@H:11]2[C:17]([NH2:19])=[O:18])=[C:7]2[N:8]=[C:29]([C:27]3[CH:26]=[CH:25][CH:24]=[C:23]([O:22][CH3:21])[N:28]=3)[NH:1][C:2]2=[N:3][CH:4]=1

参加物

4

反応物 3

HCID 517165Ammonium AcetateHCID 123253926-Methoxy-2-pyridinecarboxaldehydeHCID 117701912(1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide

生成物 1

HCID 178489871HCID 178489871、化合物収率 19%

実験手順

In a similar fashion to Compound LXXXVII, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (50.00 mg, 0.1702 mmol), 6-Methoxy-pyridine-2-carbaldehyde (25.7 mg, 0.187 mmol), and Ammonium acetate (26.2 mg, 0.340 mmol) were reacted to produce 11.03 mg (19%) of the title compound. (300 MHz, DMSO-d6) 13.30 (s, 1H), 8.01 (s, 1H), 7.89 (t, J=15 Hz, 7.5 Hz, 1H), 7.79 (m, 2H), 7.30 (d, J=9 Hz, 1H), 7.25 (s, 1H), 6.90 (d, J=8 Hz, 1H), 6.44 (s, 1H), 6.37 (s, 1H), 5.17 (t, J=17 Hz, J=9 Hz, 1H), 4.06 (s, 3H), 2.90 (s, 1H), 2.82 (s, 1H), 2.63 (d, J=8 Hz, 1H), 2.24 (d, J=8 Hz, 1H), 1.39 (d, J=8 Hz, 1H). MS=411 (M+H), HPLC: 2.53 min. (G Method)

出典と根拠

ORDレコード
ord-38064097d05b4057ba5ccabdd1f34ee4
出典データセット
uspto-grants-2016_01
特許番号
US09238656B2

関連ノート

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