Methanol → HCID 89725996、化合物

HRID 592089ノート

反応式

FC(F)(F)[C:3]([N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=2)[CH:15]=[O:16])[CH2:7][CH2:6]1)=O.[CH2:22]1OC1C.[CH3:26][OH:27]>>[OH:27][CH:26]([CH3:22])[CH2:3][N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=2)[CH:15]=[O:16])[CH2:7][CH2:6]1

参加物

反応物 3

HCID 887Methanol

HCID 6378Propylene Oxide

HCID 89726233HCID 89726233、化合物

生成物 1

HCID 89725996HCID 89725996、化合物収率 78%

反応条件

温度: 70 °C

実験手順

3-(1-(2,2,2-trifluoroacetyl)piperidin-4-yloxy)benzaldehyde (62) (1 eq) was taken in MeOH to which propylene oxide (4 eq) was added and the reaction mixture was heated in a sealed tube at 70° C. for 8 h when LCMS showed completion of reaction. The reaction mixture was concentrated and purified by column chromatography using silica gel (100-200 mesh) to afford the pure product as a colorless oil.

後処理

additionwas added
customcompletion of reaction
concentrationThe reaction mixture was concentrated
custompurified by column chromatography

出典と根拠

ORDレコード: ord-7db9488e0d204d6292b1cfb676491485
出典データセット: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09238656B2

反応ノート

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