化工社化工社 化学情報印刷レポート · 研究参考用
Phosphorus pentachloride → 2-chloro-6-fluoro-N-(4-iodophenyl)benzenecarbohydrazonoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus pentachloride | HCID 24819 | — |
| 反応物 | N-[(E)-(2-chloro-6-fluorophenyl)methylideneamino]-4-iodoaniline | HCID 90020166 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 2-chloro-6-fluoro-N-(4-iodophenyl)benzenecarbohydrazonoyl chloride | HCID 131733234 | 76.4% |
反応手順
The title compound was prepared according to the procedure described in step-2 of Intermediate-1 using (1E)-1-(2-chloro-6-fluorobenzylidene)-2-(4-iodophenyl)hydrazine (1.2 g, 3.20 mmol), PCl5 (0.990 g, 4.8 mmol) and benzene (20 mL) to afford 1.0 g of desired product. 1H NMR. (300 MHz, DMSO d6): δ 7.00 (d, J=8.7 Hz, 2H), 7.41 (d, J=8.7 Hz, 1H), 7.48-7.60 (m, 4H), 10.22 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09439890B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-96078c6f0c624753b20010b26f0d8960 |
| 出典メモ | uspto-grants-2016_09 |