化工社化工社 化学情報印刷レポート · 研究参考用
Nitrogen → Methyl 4-(bromomethyl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitrogen | HCID 947 | — |
| 反応物 | Hexane | HCID 8058 | — |
| 反応物 | 4-(Bromomethyl)benzoic acid | HCID 22599 | — |
| 反応物 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
反応手順
To a solution of 1.0 eq of 4-(bromomethyl)benzoic acid in 20 ml of methanol and 50 ml of toluene; was added dropwise 2.05 eq of trimethylsilyldiazomethane while stirring at room temperature. The reaction was titrated until a persistant pale yellow color existed from the addition of excess trimethylsilyldiazo- methane. Let stir at room temperature for 1 hr to insure the complete evolution of N2. Thin layer chromatography in 1:1 hexane:ethyl acetate indicated the disappearance of starting material and the appearance of desired ester with an Rf of 0.7.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246944 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-91ea50635080455580c7511d82a79a21 |
| 出典メモ | uspto-grants-1993_09 |